By J. Rick Turner, L.R. Cardon, John K. Hewitt
Leading researchers research how habit genetics presents an important insights into genetic and environmental affects within the improvement of biobehavioral issues. those affects are illustrated by utilizing the examples of heart problems, weight problems and consuming problems, alcohol use and abuse, and smoking habit. participants talk about the relevance of molecular genetic methods and dual and family members designs to the advanced box of habit medication research.
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Additional info for Behavior Genetic Approaches in Behavioral Medicine
If there is an association between the AI allele and alcoholism, then, it likely reflects one of two distinct possibilities. First, the AI allele may exist in linkage disequilibrium with functional polymorphisms at DRD2, a possibility INHERITANCE OF ALCOHOLISM 27 that is consistent with the population genetic data (Uhl, Blum, Noble, & Smith, 1993). Alternatively, the association may be an artifact of imperfect matching of the alcoholic and control samples. , 1993), so that failure to carefully match the alcoholic and control groups for ethnic background could produce an artifactual association, a possibility long recognized with association studies (Vogel & Motulsky, 1986).
The resting EEG of sober alcoholics evidences increased activity in the delta, theta, and beta ranges and decreased activity in the alpha range as compared to the resting EEG of nonalcoholics (Begleiter & Platz, 1972). Gabrielli et al. rs. , Ehlers & Schuckit, 1990), most have not (for a review, see Cohen, Porjesz, & Begleiter, 1991), and the relevance of resting EEG in alcoholism etiology remains uncertain. Somewhat more consistent are studies that relate alcoholism risk to EEG changes following alcohol ingestion.
Although additional twin and adoption studies might help increase our confidence in concluding that genes influence alcoholism, it was argued that the field is now appropriately more interested in attempting to determine how, rather than simply whether, genes influence risk for alcoholism. Methods that might be brought to bear on this question are discussed further in Chapters 12 and 13. Molecular genetic research in alcoholism should ultimately lead to the discovery of the specific genes that contribute to alcoholism liability and thus initiate the process of mapping the complex pathway that links genes to behavior by starting at the primary gene product level.
Behavior Genetic Approaches in Behavioral Medicine by J. Rick Turner, L.R. Cardon, John K. Hewitt