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Download PDF by Committee to Assess the Science Base for Tobacco Harm: Clearing the Smoke : Assessing the Science Base for Tobacco

By Committee to Assess the Science Base for Tobacco Harm Reduction, Board on Health Promotion and Disease Prevention, Institute of Medicine, Kathleen Stratton, Padma Shetty, Robert Wallace, Stuart Bondurant

ISBN-10: 0309072824

ISBN-13: 9780309072823

ISBN-10: 0309511844

ISBN-13: 9780309511841

Despite overwhelming facts of tobacco's destructive results and strain from anti-smoking advocates, present surveys exhibit that approximately one-quarter of all adults within the usa are people who smoke. This viewers is the objective for a wave of tobacco items and prescription drugs that declare to maintain tobacco excitement whereas decreasing its poisonous effects.

Clearing the Smoke addresses the issues in comparing no matter if such items really do lessen the well-being hazards of tobacco use. in the context of regulating such items, the committee explores key questions:

  • Does using such items lessen publicity to destructive ingredients in tobacco?
  • Is diminished publicity linked to lowered damage to health?
  • Are there surrogate symptoms of damage that may be measured fast adequate for legislation of those products?
  • What are the general public wellbeing and fitness implications?

This ebook seems on the kinds of items that can decrease damage and reports the to be had proof for his or her influence on numerous types of melanoma and different significant diseases. It additionally recommends ways to governing those items and monitoring their public healthiness effects.

With an perspective of fit skepticism, Clearing the Smoke should be vital to healthiness coverage makers, public future health officers, scientific practitioners, brands and retailers of "reduced-harm" tobacco items, and a person attempting to kind via product claims.

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Sample text

3. The evaluation of PREPs will be facilitated by the development of appropriate animal models and in vitro assays of the pathogenesis of tobaccoattributable diseases. Animal models and in vitro testing can contribute to the evaluation of individual PREPs and to the development of a scientific basis for designing and evaluating harm reduction products. Such studies could include cell culture, animal studies, and molecular studies to document specific toxicants as the most likely causative agents, to better define pathogenic effects of tobacco smoke exposure, to better explain the relationship of disease risk regression and exposure regression (dose-response relationships), and to validate biomarkers of exposure and biological effect.

Utility of preclinical 1. Dose-response data 2. Validation and 5. Long-term research to judge for conventional development of epidemiological feasibility tobacco products biomarkers studies and 2. Validation and 4. Short-term clinical surveillance development of and epidemiological biomarkers studies 4. Short-term clinical and epidemiological studies Diseasespecific summary data (Chapter 5; Section II) Risk Management 1. Risk reduction is feasible 2. Risk reduction not yet demonstrated 6. Public health impact is unknown 5.

Htm [accessed September 11, 2000]. S. Public Health Service. 1964. Smoking and Health: Report of the Advisory Committee to the Surgeon General of the Public Health Service. S.

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Clearing the Smoke : Assessing the Science Base for Tobacco Harm Reduction by Committee to Assess the Science Base for Tobacco Harm Reduction, Board on Health Promotion and Disease Prevention, Institute of Medicine, Kathleen Stratton, Padma Shetty, Robert Wallace, Stuart Bondurant


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