By Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention, Kathleen Stratton, Alicia Gable, Padma Shetty, Marie McCormick
First in a chain of stories from the IOM Immunization security overview Committee, offers an evaluate of the proof concerning a hypothesized causal organization among the measles-mumps-rubella vaccine and autism, and the committee's conclusions and suggestions. Softcover.
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First in a chain of stories from the IOM Immunization defense overview Committee, offers an evaluate of the proof relating to a hypothesized causal organization among the measles-mumps-rubella vaccine and autism, and the committee's conclusions and suggestions. Softcover.
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Additional info for Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism
Autopsy studies of a small number of brains of individuals who had autism have shown neuroanatomic abnormalities, including decreased cell size, increased cell density, and stunting of dendritic branching bilaterally in the limbic system (Bauman and Kemper, 1997; Kemper and Bauman, 1998). The limbic system is important for learning, memory, emotion, and behavior. A decrease in Purkinje cell density and, to a lesser extent, granule cell density in the cerebellum has also been described (Bauman, 1999; Bauman and Kemper, 1997).
The DSM-IV criteria for Asperger’s are the same as those for autistic disorder with respect to social impairments and abnormal patterns of behavior and interests but describe no evidence of significant language impairment and near-normal IQ. Because of the less-impaired language development, the syndrome often becomes apparent later in childhood (34 years of age). Rett’s syndrome, first described in 1966, is evident only in girls and only after a brief period of normal development. The syndrome is marked by development of motor impairments (apraxia and ataxia), deceleration of head growth, profound mental retardation, and breathing dysfunctions.
These findings have not been replicated by other laboratories. , 1993, 1999). Although an association between Crohn’s disease and autism has not been suggested, these findings have bearing on the plausibility argument for persistent vaccine-strain measles virus infection. The identification of vaccine-strain measles virus in Crohn’s patients remains highly controversial. Virus has not been isolated from patient samples by culture. , 1993). , 2000). , 1995). There is support for the biologic plausibility of persistent measles virus infection, but the only reproducible and convincing evidence for this is in the CNS.
Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism by Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention, Kathleen Stratton, Alicia Gable, Padma Shetty, Marie McCormick